Journal article

ESTIMATING THE FRACTION OF INVARIABLE CODONS WITH A CAPTURE-RECAPTURE METHOD

A SIDOW, T NGUYEN, TP SPEED

JOURNAL OF MOLECULAR EVOLUTION | SPRINGER VERLAG | Published : 1992

Abstract

A codon-based approach to estimating the number of variable sites in a protein is presented. When first and second positions of codons are assumed to be replacement positions, a capture-recapture model can be used to estimate the number of variable codons from every pair of homologous and aligned sequences. The capture-recapture estimate is compared to a maximum likelihood estimate of the number of variable codons and to previous approaches that estimate the number of variable sites (not codons) in a sequence. Computer simulations are presented that show under which circumstances the capture-recapture estimate can be used to correct biases in distance matrices. Analysis of published sequence..

View full abstract

University of Melbourne Researchers