Journal article

Loss of cochlear nucleus neurons following aminoglycoside antibiotics or cochlear removal

NJ Rogers, DR Moore, SJ O'Leary

ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY | SAGE PUBLICATIONS INC | Published : 1998

Abstract

This study compared the effects of aminoglycoside ototoxicity and surgical ablation of the cochlea in infancy on the survival of neurons in the rat cochlear nucleus (CN). Ototoxicity was induced by a single, systemic dose of gentamicin sulfate and furosemide on postnatal day 6 (P6), P7, or P10, and assessed by the elevation of auditory brain stem response thresholds, as described in a companion paper. Unilateral cochlear removals were performed under Saffan anesthesia on P6, P9, and P12. Rats were painlessly sacrificed in adulthood, and the formalin-perfused brains and cochleas were embedded in wax, sectioned, and stained. Ototoxic treatment at P6 through P10 did not reduce neuron counts in ..

View full abstract

University of Melbourne Researchers