Journal article

Pharmacokinetics of midazolam in Vietnamese subjects

KR Balson, DJ Morgan, BH Richmond, ME McAlindon, SL Elliott, ND Yeomans

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | BLACKWELL SCIENCE | Published : 1996

Abstract

In order to examine the investigators' clinical suspicion that Vietnamese patients were more sensitive to the sedative effects of midazolam than were Caucasians, the pharmacokinetics of a single, weight-adjusted intravenous dose of midazolam (0.05 mg/kg) were compared in a group of healthy Caucasian and Vietnamese male volunteers. The Vietnamese group (n = 8) had a significantly lower height, lean body mass and mean weight (59.8 +/- 5.5 vs 72.1 +/- 8.1 kg, respectively) compared with the Caucasian group (n = 8). No significant differences were found between the Vietnamese and Caucasian groups with regard to distribution half-life of midazolam (8.38 +/- 13.1 vs 1.49 +/- 0.63 min, respectively..

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