Journal article

Gastric microbleeding following single and repeated dosing with naproxen

ME McAlindon, GA Cook, SL Elliott, CJ Hawkey, ND Yeomans

ALIMENTARY PHARMACOLOGY & THERAPEUTICS | BLACKWELL SCIENCE LTD | Published : 1995

Abstract

BACKGROUND: Adaptation to gastric damage from nonsteroidal anti-inflammatory drugs (NSAID) has been observed during ongoing dosage in rats and humans. However, this does not always occur, and our previous data suggest that NSAID half-life may be a determining factor. AIM: To investigate whether adaptation occurs during 1 week of naproxen administration in humans. SUBJECTS: Thirteen healthy volunteers were studied at baseline, and after one or seven daily doses of naproxen 750 mg. Gastric microbleeding was measured 4 h after naproxen in gastric washings collected during a 30-min period. Serum thromboxane B concentrations were also assayed, as a marker of cyclo-oxygenase inhibition. RESULTS: M..

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