Optical Coherence Tomography Reveals Changes to Corneal Reflectivity and Thickness in Individuals with Tear Hyperosmolarity
Laura Adelaide Deinema, Algis Jonas Vingrys, Holly Rose Chinnery, Laura Elizabeth Downie
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | Published : 2017
PURPOSE: To investigate whether tear hyperosmolarity, a feature of dry eye disease (DED), affects central corneal thickness (CCT), corneal light reflectivity, and/or tear film reflectivity. METHODS: This prospective, cross-sectional study involved 48 participants (38 with hyperosmolar tears and 10 controls with normo-osmolar tears). Symptoms and signs of DED (tear osmolarity, sodium fluorescein tear break-up time, ocular surface staining, Schirmer test) were assessed. CCT, and the reflectivity of the cornea and the tear-epithelial interface were quantified relative to background noise using Fourier-domain optical coherence tomography (FD-OCT). RESULTS: CCT of eyes with severe tear hyperosmol..View full abstract
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Supported by a Rebecca L Cooper Medical Research Foundation Grant (LED). The funding organization had no role in the design or conduct of this research.