Journal article
Bim expression in endothelial cells and pericytes is essential for regression of the fetal ocular vasculature
S Wang, IS Zaitoun, RP Johnson, N Jamali, Z Gurel, CM Wintheiser, A Strasser, V Lindner, N Sheibani, CM Sorenson
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2017
Abstract
Apoptosis plays a central role in developmental and pathological angiogenesis and vessel regression. Bim is a pro-apoptotic Bcl-2 family member that plays a prominent role in both developmental and pathological ocular vessel regression, and neovascularization. Endothelial cells (EC) and pericytes (PC) each play unique roles during vascular development, maintenance and regression. We recently showed that germline deletion of Bim results in persistent hyaloid vasculature, increased retinal vascular density and prevents retinal vessel regression in response to hyperoxia. To determine whether retinal vascular regression is attributable to Bim expression in EC or PC we generated mice carrying a c..
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Awarded by National Eye Institute
Funding Acknowledgements
This work was funded by Lions Pediatric Ophthalmology Research Fund and Retina Research Foundation/Daniel M. Albert Chair. CMS was supported by grant from the National Institutes of Health R21EY023024. NS is supported by NIH grant R24 EY022883, P30 CA014520 UW Paul P. Carbone Cancer Center support grant, P30 EY016665, and an unrestricted departmental award from Research to Prevent Blindness. NS is a recipient of an award from the Retina Research Foundation. RPJ is a recipient of a Hilldale Fellowship at the University of Wisconsin -Madison. Generation of the Tg (Pdgfrb-cre)45Vli mice was enabled by the Mouse Transgenic and In Vivo Imaging Core Facility supported by P30GM103392 (VL).