Quantitative proteomics in Giardia duodenalis-Achievements and challenges
Samantha J Emery, Ernest Lacey, Paul A Haynes
MOLECULAR AND BIOCHEMICAL PARASITOLOGY | ELSEVIER SCIENCE BV | Published : 2016
Giardia duodenalis (syn. G. lamblia and G. intestinalis) is a protozoan parasite of vertebrates and a major contributor to the global burden of diarrheal diseases and gastroenteritis. The publication of multiple genome sequences in the G. duodenalis species complex has provided important insights into parasite biology, and made post-genomic technologies, including proteomics, significantly more accessible. The aims of proteomics are to identify and quantify proteins present in a cell, and assign functions to them within the context of dynamic biological systems. In Giardia, proteomics in the post-genomic era has transitioned from reliance on gel-based systems to utilisation of a diverse arra..View full abstract
SJE acknowledges funding from the Australian Government in the form of an APA scholarship, as well as financial support from Macquarie University. SJE also acknowledges ongoing support received from colleagues at Microbial Screening Technologies. PAH wishes to acknowledge research support from the Australian Research Council training centre for Molecular Technologies in the Food Industry. PAH completed work on this manuscript while on sabbatical at UCSD, and wishes to acknowledge the gracious support of Majid Ghassemian and Betsy Komives, and thank Wayne Dutschke for continued support and encouragement.