Toll-like receptors at the ocular surface.
Eric Pearlman, Angela Johnson, Gautam Adhikary, Yan Sun, Holly R Chinnery, Todd Fox, Mark Kester, Paul G McMenamin
Ocul Surf | Published : 2008
The Toll-like receptor (TLR) family of pathogen recognition molecules has an important role in recognizing microbial pathogens and microbial breakdown products. Activation of TLRs in the corneal epithelium induces CXC chemokine production and recruitment of neutrophils to the corneal stroma. Although essential for pathogen killing, neutrophils can cause extensive tissue damage, leading to visual impairment and blindness. In this review, we examine the role of TLRs in microbial keratitis and in noninfectious corneal inflammation, most commonly associated with contact lens wear. we present recent findings on TLR signaling pathways in the cornea, including MyD88- and TRIF-dependent responses an..View full abstract