Journal article

Associations of childhood and adult obesity with left ventricular structure and function

H Yang, QL Huynh, AJ Venn, T Dwyer, TH Marwick

INTERNATIONAL JOURNAL OF OBESITY | NATURE PUBLISHING GROUP | Published : 2017

Abstract

BACKGROUND: Overweight and obesity are associated with left ventricular (LV) dysfunction. We sought whether echocardiographic evidence of abnormal adult cardiac structure and function was related to childhood or adult adiposity. METHODS: This study included 159 healthy individuals aged 7-15 years and followed until age 36-45 years. Anthropometric measurements were performed both at baseline and follow-up. Cardiac structure (indexed left atrial volume (LAVi), left ventricular mass (LVMi)) and LV function (global longitudinal strain (GLS), mitral e') were assessed using standard echocardiography at follow-up. Conventional cutoffs were used to define abnormal LAVi, LVMi, GLS and mitral annular ..

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Grants

Awarded by National Heart Foundation of Australia


Funding Acknowledgements

The CDAH study was funded by the Australian National Health and Medical Research Council, the Australian National Heart Foundation, the Tasmanian Community Fund and Veolia Environmental Services, and the contributions of the CDAH's project manager, Marita Dalton, all other project staff and volunteers, and the study participants. HY is supported by a Health Professional Scholarship from the National Heart Foundation of Australia (100307).