Journal article

The dynamics of functional connectivity in neocortical focal epilepsy

Mangor Pedersen, Amir Omidvarnia, Evan K Curwood, Jennifer M Walz, Genevieve Rayner, Graeme D Jackson



Focal epilepsy is characterised by paroxysmal events, reflecting changes in underlying local brain networks. To capture brain network activity at the maximal temporal resolution of the acquired functional magnetic resonance imaging (fMRI) data, we have previously developed a novel analysis framework called Dynamic Regional Phase Synchrony (DRePS). DRePS measures instantaneous mean phase coherence within neighbourhoods of brain voxels. We use it here to examine how the dynamics of the functional connections of regional brain networks are altered in neocortical focal epilepsy. Using task-free fMRI data from 21 subjects with focal epilepsy and 21 healthy controls, we calculated the power spectr..

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Awarded by National Health and Medical Research Council (NHMRC) of Australia

Awarded by NHMRC practitioner's fellowship

Funding Acknowledgements

We thank Mira Semmelroch, Donna Parker and Magdalena Kowalczyk for assistance with fMRI data acquisition. This study was supported by the National Health and Medical Research Council (NHMRC) of Australia (#628952). The Florey Institute of Neuroscience and Mental Health acknowledges the strong support from the Victorian Government and in particular the funding from the Operational Infrastructure Support Grant. We also acknowledge the facilities, and the scientific and technical assistance of the National Imaging Facility (NIF) at the Florey node and The Victorian Biomedical Imaging Capability (VBIC). GJ is supported by an NHMRC practitioner's fellowship (#1060312). MP was supported by The University of Melbourne scholarships (MIRS & MIFRS).