Journal article

Cortico-amygdalar maturational coupling is associated with depressive symptom trajectories during adolescence

Nandita Vijayakumar, Nicholas B Allen, Meg Dennison, Michelle L Byrne, Julian G Simmons, Sarah Whittle

NEUROIMAGE | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2017

Abstract

BACKGROUND: Adolescence is characterized by increasing prevalence of depressive symptomatology, along with significant structural brain development. While much research has examined focal abnormalities in gray matter structure underlying depression, we employed a structural coupling approach to examine whether longitudinal associations between amygdala and cortical development (referred to as maturational coupling) was related to concurrent changes in depressive symptomatology during adolescence. METHOD: 166 participants underwent up to three MRI scans (367 scans) between 11 and 20 years of age. Depressive symptoms were measured at three coinciding time points using the Center for Epidemiolo..

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Grants

Awarded by National Health and Medical Research Council (NHMRC; Australia)


Awarded by Australian Research Council (ARC)


Awarded by NHMRC Career Development Fellowship


Awarded by National Institute of Health


Awarded by NATIONAL INSTITUTE OF MENTAL HEALTH


Funding Acknowledgements

The authors report no conflicts of interest. Neuroimaging analysis was facilitated by the Neuropsychiatry Imaging Laboratory at the Melbourne Neuropsychiatry Centre. The authors would like to thank the Brain Research Institute and Royal Children's Hospital for support in acquiring the neuroimaging data, and the families who participated in the study. This research was supported by grants from the Colonial Foundation, the National Health and Medical Research Council (NHMRC; Australia; Program Grant 350241) and the Australian Research Council (ARC; Discovery Grant DP0878136). Dr. Whittle is supported by a NHMRC Career Development Fellowship (ID: 1007716) and Dr Vijayakumar is supported by National Institute of Health R01 MH107418 (PI: Pfeifer)