SCIPA Switch-On: A Randomized Controlled Trial Investigating the Efficacy and Safety of Functional Electrical Stimulation-Assisted Cycling and Passive Cycling Initiated Early After Traumatic Spinal Cord Injury
Mary P Galea, Maya G Panisset, Doa El-Ansary, Sarah A Dunlop, Ruth Marshall, Jillian M Clark, Leonid Churilov
NEUROREHABILITATION AND NEURAL REPAIR | SAGE PUBLICATIONS INC | Published : 2017
Background. Substantial skeletal muscle atrophy after spinal cord injury (SCI) carries significant repercussions for functional recovery and longer-term health. Objective. To compare the efficacy, safety, and feasibility of functional electrical stimulation-assisted cycling (FESC) and passive cycling (PC) to attenuate muscle atrophy after acute SCI. Methods. This multicenter, assessor-blinded phase I/II trial randomized participants at 4 weeks post-SCI to FESC or PC (4 sessions per week, 1 hour maximum per session, over 12 weeks). The primary outcome measure was mean maximum cross-sectional area (CSA) of thigh and calf muscles (magnetic resonance imaging), and secondary outcome measures comp..View full abstract
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Awarded by National Health and Medical Research Council of Australia
The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The study was funded by the Transport Accident Commission (Victorian Neurotrauma Initiative) and the National Health and Medical Research Council of Australia (APP1042653).