Journal article

Elevated paternal glucocorticoid exposure modifies memory retention in female offspring

Shlomo Yeshurun, Jake Rogers, Annabel K Short, Thibault Renoir, Terence Y Pang, Anthony J Hannan



Recent studies have demonstrated that behavioral traits are subject to transgenerational modification by paternal environmental factors. We previously reported on the transgenerational influences of increased paternal stress hormone levels on offspring anxiety and depression-related behaviors. Here, we investigated whether offspring sociability and cognition are also influenced by paternal stress. Adult C57BL/6J male mice were treated with corticosterone (CORT; 25mg/L) for four weeks prior to paired-matings to generate F1 offspring. Paternal CORT treatment was associated with decreased body weights of female offspring and a marked reduction of the male offspring. There were no differences in..

View full abstract


Awarded by NHMRC project

Awarded by ARC FT3 Future Fellowship

Funding Acknowledgements

The authors would like to thank Ms Shanshan Li for technical assistance and other members of the laboratory for useful discussions. This work was funded through an NHMRC project grant to AJH and TYP (GNT1083468), an ARC FT3 Future Fellowship to AJH (FT100100835) and supported by the Victorian Government through the Operational Infrastructure Scheme. AJH is an NHMRC Principal Research Fellow (GNT1117148).