Journal article

Clinical Significance of Lipid-Rich Plaque Detected by Optical Coherence Tomography A 4-Year Follow-Up Study

Lei Xing, Takumi Higuma, Zhao Wang, Aaron D Aguirre, Kyoichi Mizuno, Masamichi Takano, Harold L Dauerman, Seung-Jung Park, Yangsoo Jang, Chong-Jin Kim, Soo-Joong Kim, So-Yeon Choi, Tomonori Itoh, Shiro Uemura, Harry Lowe, Darren L Walters, Peter Barlis, Stephen Lee, Amir Lerman, Catalin Toma Show all



BACKGROUND: Lipid-rich plaque (LRP) is thought to be a precursor to cardiac events. However, its clinical significance in coronary arteries has never been systematically investigated. OBJECTIVES: This study investigated the prevalence and clinical significance of LRP in the nonculprit region of the target vessel in patients undergoing percutaneous coronary intervention (PCI). METHODS: The study included 1,474 patients from 20 sites across 6 countries undergoing PCI, who had optical coherence tomography (OCT) imaging of the target vessel. Major adverse cardiac events (MACE) were defined as a composite of cardiac death, acute myocardial infarction, and ischemia-driven revascularization. Patien..

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Awarded by American Heart Association

Awarded by National Institutes of Health

Funding Acknowledgements

Dr. Jang is supported by Mr. and Mrs. Michael and Kathryn Park and by Mrs. and Mr. Gill and Allan Gray. Dr. Aguirre is supported by American Heart Association grant 14FTF20380185. Mr. Fujimoto is supported by National Institutes of Health grant R01-CA075289-18; and holds royalties from IP owned by MIT and licensed to St. Jude Medical. Dr. Ik-Kyung Jang has received grants and consulting fees from St. Jude Medical. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. Deepak L. Bhatt, MD, MPH, served as Guest Editor-in-Chief for this paper.