Effect of APOE Genotype on Amyloid Deposition, Brain Volume, and Memory in Cognitively Normal Older Individuals
Yen Ying Lim, Robert Williamson, Simon M Laws, Victor L Villemagne, Pierrick Bourgeat, Christopher Fowler, Stephanie Rainey-Smith, Olivier Salvado, Ralph N Martins, Christopher C Rowe, Colin L Masters, Paul Maruff
JOURNAL OF ALZHEIMERS DISEASE | IOS PRESS | Published : 2017
BACKGROUND: The association between the apolipoprotein E (APOE) ɛ4 allele and high risk of developing Alzheimer's disease (AD) dementia before the age of 80 has been recognized for over 30 years. However, the timing and mode of action of APOE is not understood, nor has there been a detailed analysis of the effect of APOE genotype on memory, hippocampal volume, and amyloid-β (Aβ) levels in cognitively normal adults. OBJECTIVE: Examine the effect of APOE allelic genotype on the relationship between Aβ levels, hippocampal volume, and memory in cognitively normal adults. METHODS: This is a cross-sectional study of 989 cognitively normal older adults enrolled in the Australian Imaging, Biomarkers..View full abstract
Alzheimer's Australia (Victoria and Western Australia) assisted with promotion of the study and the screening of telephone calls from volunteers. The AIBL team wishes to thank the clinicians who referred patients with MCI or AD to the study: Associate Professor Brian Chambers, Professor Edmond Chiu, Dr. Roger Clarnette, Associate Professor David Darby, Dr. Mary Davison, Dr. John Drago, Dr. Peter Drysdale, Dr. Jacqueline Gilbert, Dr. Kwang Lim, Professor Nicola Lautenschlager, Dr. Dina LoGiudice, Dr. Peter McCardle, Dr Steve McFarlane, Dr. Alastair Mander, Dr. John Merory, Professor Daniel O'Connor, Dr. Ron Scholes, Dr. Mathew Samuel, Dr. Darshan Trivedi, and Associate Professor Michael Woodward. We thank all those who participated in the study for their commitment and dedication to helping advance research into the early detection and causation of AD. YYL is funded by the NHMRC-ARC Dementia Research Development Fellowship.