Journal article

Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci

Tin Aung, Mineo Ozaki, Mei Chin Lee, Ursula Schlotzer-Schrehardt, Gudmar Thorleifsson, Takanori Mizoguchi, Robert P Igo, Aravind Haripriya, Susan E Williams, Yury S Astakhov, Andrew C Orr, Kathryn P Burdon, Satoko Nakano, Kazuhiko Mori, Khaled Abu-Amero, Michael Hauser, Zheng Li, Gopalakrishnan Prakadeeswari, Jessica N Cooke Bailey, Alina Popa Cherecheanu Show all

Nature Genetics | NATURE PUBLISHING GROUP | Published : 2017

Grants

Awarded by National Medical Research Council, Singapore


Awarded by Interdisziplinares Zentrum fur Klinische Forschung from Germany


Awarded by US National Institutes of Health


Awarded by Center for Inherited Disease Research (CIDR)


Awarded by National Natural Science Foundation of China


Awarded by National Major Scientific and Technological Special Project for Significant New Drugs Development


Awarded by Leading Talents-High-Level Talents of the Health System of Beijing


Funding Acknowledgements

This research is supported by the Biomedical Research Council, Agency for Science, Technology and Research, Singapore (to C.C.K.), by the Glaucoma Foundation of New York (to C.C.K.), by grants from the National Medical Research Council, Singapore NMRC/TCR/008-SERI/2013 and NMRC/STAR/0023/2014 to T.A. and NMRC/CBRG/0032/2013 to E.N.V.), by the Interdisziplinares Zentrum fur Klinische Forschung (IZKF-E23) from Germany to F.P. and U.S.-S., and by grants from the US National Institutes of Health: UM1 CA186107, R01 CA49449, R01 AR056291, R01 CA131332, P01 CA055075, R01 CA134958 and R01 EY015473 to J.L.W. For XFS cases in the US GWAS data set, genotyping services were provided through a grant to J.L.W. (HG008597) by the Center for Inherited Disease Research (CIDR). CIDR is fully funded through a federal contract from the US National Institutes of Health to The Johns Hopkins University, contract HHSN268201200008I. The Beijing, China, collection was supported by funding from the National Natural Science Foundation of China (81030016 and 81570837), the Program of Beijing Scholars (2013), the National Major Scientific and Technological Special Project for Significant New Drugs Development (2011ZX09302-007-05) and Leading Talents-High-Level Talents of the Health System of Beijing (2009-1-05) to N. Wang. We dedicate this article to the ophthalmologist Eva Forsman from Finland who passed away after diagnosing all of the exfoliation syndrome cases from Finland.