Journal article

Reevaluation of SNP heritability in complex human traits

Doug Speed, Na Cai, Michael R Johnson, Sergey Nejentsev, David J Balding

Nature Genetics | NATURE PUBLISHING GROUP | Published : 2017

University of Melbourne Researchers


Awarded by UK Medical Research Council

Awarded by British Heart Foundation

Funding Acknowledgements

Access to Wellcome Trust Case Control Consortium data was authorized as work related to the project "Genome-wide association study of susceptibility and clinical phenotypes in epilepsy," while access to Children's Hospital of Philadelphia (CHOP) data was granted under Project 49228-1, "Assumptions underlying estimates of SNP heritability." We thank A. Molloy, J. Mills and L. Brody for permission to use genotype data from the Trinity College Dublin Student Study and S. Langley for help accessing the CHOP data. This work is funded by the UK Medical Research Council under grant MR/L012561/1 (awarded to D.S.) and the British Heart Foundation under grant RG/10/12/28456 (the UCLEB Consortium) and is supported by researchers at the National Institute for Health Research (NIHR) University College London Hospitals Biomedical Research Centre. N.C. is an ESPOD Fellow from the European Molecular Biology Laboratory, European Bioinformatics Institute, and Wellcome Trust Sanger Institute. M.R.J. receives funding from the Imperial College NIHR Biomedical Research Centre (BRC) Scheme. S.N. is a Wellcome Trust Senior Research Fellow in Basic Biomedical Science and is also supported by the NIHR Cambridge Biomedical Research Centre. Analyses were performed with the use of the UCL Computer Science Cluster and the help of the CS Technical Support Group, as well as the use of the UCL Legion High-Performance Computing Facility (Legion@UCL) and associated support services.