Journal article
Fibrinogen Early In Severe Trauma studY (FEISTY): Study protocol for a randomised controlled trial
J Winearls, M Wullschleger, E Wake, C Hurn, J Furyk, G Ryan, M Trout, J Walsham, A Holley, J Cohen, M Shuttleworth, W Dyer, G Keijzers, JF Fraser, J Presneill, D Campbell
Trials | BMC | Published : 2017
Open access
Abstract
Background: Haemorrhage is a leading cause of death in severe trauma. Fibrinogen plays a critical role in maintaining haemostasis in traumatic haemorrhage. Early fibrinogen replacement is recommended by several international trauma guidelines using either fibrinogen concentrate (FC) or cryoprecipitate (Cryo). There is limited evidence to support one product over the other with widespread geographic and institutional variation in practice. This pilot trial is the first randomised controlled trial comparing FC to Cryo in traumatic haemorrhage. Methods/design: The Fibrinogen Early In Severe Trauma studY (FEISTY) is an exploratory, multicentre, randomised controlled trial comparing FC to Cryo fo..
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Awarded by National Blood Authority
Funding Acknowledgements
The programme of trauma research is supported by grants from the Emergency Medicine Foundation (Grant ID: EMPJ357R25-2016), National Blood Authority (Grant ID: 127) and Gold Coast University Hospital (Grant ID: 150-16.6.16). This trial is supported by TEM International and CSL Behring in terms of materials only. There is no industry input into trial design, data collection, data analysis or dissemination of results. Funding will managed by the coordinating site - Gold Coast University Hospital and University of Queensland.