Journal article

White matter connectivity disruptions in early and chronic schizophrenia

MA Di Biase, VL Cropley, BT Baune, J Olver, GP Amminger, C Phassouliotis, C Bousman, PD McGorry, I Everall, C Pantelis, A Zalesky

PSYCHOLOGICAL MEDICINE | CAMBRIDGE UNIV PRESS | Published : 2017

Abstract

BACKGROUND: White matter disruptions in schizophrenia have been widely reported, but it remains unclear whether these abnormalities differ between illness stages. We mapped the connectome in patients with recently diagnosed and chronic schizophrenia and investigated the extent and overlap of white matter connectivity disruptions between these illness stages. METHODS: Diffusion-weighted magnetic resonance images were acquired in recent-onset (n = 19) and chronic patients (n = 45) with schizophrenia, as well as age-matched controls (n = 87). Whole-brain fiber tracking was performed to quantify the strength of white matter connections. Connections were tested for significant streamline count re..

View full abstract

Grants

Awarded by National Health and Medical Research Council


Awarded by Cooperative Research Centre for Mental Health - Commonwealth of Australia, Department of Innovation, Industry, Science and Research


Awarded by Brain and Behaviour Research Foundation


Awarded by NHMRC


Funding Acknowledgements

This study was supported by the National Health and Medical Research Council (1065742; C.P. 628386, 1105825; V.C. 628880); the Cooperative Research Centre for Mental Health, funded by the Commonwealth of Australia, Department of Innovation, Industry, Science and Research (20100104); Australian Rotary Health (M.A.D. Ian Scott Ph.D. Scholarship in Mental Health), the Brain and Behaviour Research Foundation (C.P. 18722; V.C. 21660; C.B. 20526) and the University of Melbourne. A.Z. was supported by a NHMRC Career Development Fellowship (GNT1047648).