Journal article

Erythrocyte polyunsaturated fatty acid composition is associated with depression and FADS genotype in Caucasians

Lachlan Cribb, Jenifer Murphy, Amy Froud, Georgina Oliver, Chad A Bousman, Chee H Ng, Jerome Sarris

NUTRITIONAL NEUROSCIENCE | TAYLOR & FRANCIS LTD | Published : 2018

Abstract

BACKGROUND: Polyunsaturated fatty acids (PUFAs) play an important role in the pathophysiology of major depressive disorder (MDD), related, in part, to their role in inflammatory systems. The enzymes δ-5 and δ-6 desaturase are the rate-limiting steps in the metabolism of PUFAs and are encoded in the genes fatty acid desaturase (FADS) 1 and 2, respectively. Single nucleotide polymorphisms (SNPs) and haplotypes within the FADS gene cluster have been shown to influence PUFA composition. AIM: The objective of this study was to determine whether key omega-3 (n-3) and omega-6 (n-6) fatty acids may be associated with depression, and to explore the role of FADS genotype in PUFA variation. METHODS: Fo..

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