Journal article
Erythrocyte polyunsaturated fatty acid composition is associated with depression and FADS genotype in Caucasians
Lachlan Cribb, Jenifer Murphy, Amy Froud, Georgina Oliver, Chad A Bousman, Chee H Ng, Jerome Sarris
NUTRITIONAL NEUROSCIENCE | TAYLOR & FRANCIS LTD | Published : 2018
Abstract
BACKGROUND: Polyunsaturated fatty acids (PUFAs) play an important role in the pathophysiology of major depressive disorder (MDD), related, in part, to their role in inflammatory systems. The enzymes δ-5 and δ-6 desaturase are the rate-limiting steps in the metabolism of PUFAs and are encoded in the genes fatty acid desaturase (FADS) 1 and 2, respectively. Single nucleotide polymorphisms (SNPs) and haplotypes within the FADS gene cluster have been shown to influence PUFA composition. AIM: The objective of this study was to determine whether key omega-3 (n-3) and omega-6 (n-6) fatty acids may be associated with depression, and to explore the role of FADS genotype in PUFA variation. METHODS: Fo..
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Grants
Awarded by National Health and Medical Research Council Clinical Research Fellowship
Awarded by NHMRC
Awarded by NHMRC Biomedical Research Fellowship
Funding Acknowledgements
JS is supported by National Health and Medical Research Council Clinical Research Fellowship (APP1125000). The depression data were derived from a clinical trial sponsored by NHMRC project grant APP1048222. CAB is supported by an NHMRC Biomedical Research Fellowship (APP1127700).