Journal article

Erythrocyte polyunsaturated fatty acid composition is associated with depression and FADS genotype in Caucasians

Lachlan Cribb, Jenifer Murphy, Amy Froud, Georgina Oliver, Chad A Bousman, Chee H Ng, Jerome Sarris

NUTRITIONAL NEUROSCIENCE | TAYLOR & FRANCIS LTD | Published : 2018

Abstract

BACKGROUND: Polyunsaturated fatty acids (PUFAs) play an important role in the pathophysiology of major depressive disorder (MDD), related, in part, to their role in inflammatory systems. The enzymes δ-5 and δ-6 desaturase are the rate-limiting steps in the metabolism of PUFAs and are encoded in the genes fatty acid desaturase (FADS) 1 and 2, respectively. Single nucleotide polymorphisms (SNPs) and haplotypes within the FADS gene cluster have been shown to influence PUFA composition. AIM: The objective of this study was to determine whether key omega-3 (n-3) and omega-6 (n-6) fatty acids may be associated with depression, and to explore the role of FADS genotype in PUFA variation. METHODS: Fo..

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Grants

Awarded by National Health and Medical Research Council Clinical Research Fellowship


Awarded by NHMRC


Awarded by NHMRC Biomedical Research Fellowship


Funding Acknowledgements

JS is supported by National Health and Medical Research Council Clinical Research Fellowship (APP1125000). The depression data were derived from a clinical trial sponsored by NHMRC project grant APP1048222. CAB is supported by an NHMRC Biomedical Research Fellowship (APP1127700).