Journal article

Elevated sympathetic activity, endothelial dysfunction, and late hypertension after repair of coarctation of the aorta

Melissa GY Lee, Robyn A Hemmes, Jonathan Mynard, Elisabeth Lambert, Geoffrey A Head, Michael MH Cheung, Igor E Konstantinov, Christian P Brizard, Gavin Lambert, Yves d'Udekem



BACKGROUND: There is a high prevalence of late hypertension after coarctation repair. The relative contribution of elevated sympathetic tone and endothelial dysfunction to its development is unknown. This study aims to investigate the neural profile of coarctation patients including muscle sympathetic nerve activity testing to directly measure sympathetic nervous activity. METHODS: Twenty-three patients aged ≥18years with a coarctation repair underwent measurements of clinic and 24-h blood pressures, muscle sympathetic nerve activity, sympathetic and cardiac baroreflex functions, digital endothelial function, and ambulatory arterial stiffness index. Median age at repair was 1.2months (interq..

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Awarded by National Health and Medical Research Council (NHMRC)

Awarded by Noel and Imelda Foster Research Award

Awarded by NHMRC

Funding Acknowledgements

This project was supported by the Victorian Government's Operational Infrastructure Support Program and a HeartKids Grant-in-Aid research grant. Melissa Lee was supported by a National Health and Medical Research Council (NHMRC) Medical Research Postgraduate Scholarship (1134274), a National Heart Foundation Health Professional Scholarship supported by The Noel and Imelda Foster Research Award (100681), an Avant Doctors-in-Training research scholarship, and an Australian Government Research Training Program Scholarship. Geoff Head, Gavin Lambert, and Yves d'Udekem (1082186) are supported by fellowships from the NHMRC.