Genetic variation at the Th2 immune gene IL13 is associated with IgE-mediated paediatric food allergy

SE Ashley; H-TT Tan; R Peters; KJ Allen; P Vuillermin; SC Dharmage; MLK Tang; J Koplin; A Lowe; A-L Ponsonby; J Molloy; MC Matheson; R Saffery; JA Ellis; D Martino

Journal article

Genetic variation at the Th2 immune gene IL13 is associated with IgE-mediated paediatric food allergy

SE Ashley, H-TT Tan, R Peters, KJ Allen, P Vuillermin, SC Dharmage, MLK Tang, J Koplin, A Lowe, A-L Ponsonby, J Molloy, MC Matheson, R Saffery, JA Ellis, D Martino

CLINICAL AND EXPERIMENTAL ALLERGY | WILEY | Published : 2017

DOI: 10.1111/cea.12942

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Abstract

BACKGROUND: Food allergies pose a considerable world-wide public health burden with incidence as high as one in ten in 12-month-old infants. Few food allergy genetic risk variants have yet been identified. The Th2 immune gene IL13 is a highly plausible genetic candidate as it is central to the initiation of IgE class switching in B cells. OBJECTIVE: Here, we sought to investigate whether genetic polymorphisms at IL13 are associated with the development of challenge-proven IgE-mediated food allergy. METHOD: We genotyped nine IL13 "tag" single nucleotide polymorphisms (tag SNPs) in 367 challenge-proven food allergic cases, 199 food-sensitized tolerant cases and 156 non-food allergic controls f..

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University of Melbourne Researchers

Jennifer Koplin Author Paediatrics Royal Children's Hospital

Peter Vuillermin Author Paediatrics Royal Children's Hospital

Adrian Lowe Author Melbourne School of Population and Global Health

Katie Allen Author Paediatrics Royal Children's Hospital

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Grants

Awarded by National Health and Medical Research Council

Awarded by Australian Research Council

Awarded by National Health and Medical Research Council of Australia

Funding Acknowledgements

National Health and Medical Research Council, Grant/Award Number: Career Development Fellowship APP1045902, Senior Research Fellowship APP 1110200, Project grant APP607370, Project grant APP454856, Project grant APP1084017, Project grant APP1082037, Project grant APP1076667, Project grant APP1047485, Project grant APP1030701, Project grant APP102997, Project grant APP1009044, Project grant 1029690, Early Career Fellowship 1072752, Early Career Fellowship 1054592, Career Development Fellowship APP628514; Australian Research Council, Grant/Award Number: Future Fellowship FT120100253