Journal article

Characterization of the coagulation profile in children with liver disease and extrahepatic portal vein obstruction or shunt

William Beattie, Maria Magnusson, Winita Hardikar, Paul Monagle, Vera Ignjatovic

PEDIATRIC HEMATOLOGY AND ONCOLOGY | TAYLOR & FRANCIS INC | Published : 2017

Abstract

INTRODUCTION: Chronic liver disease causes a disruption of procoagulant and anticoagulant factors, resulting in a fragile state, prone to increased rates of both bleeding and thrombosis. Currently, there is limited literature describing the changes observed in pediatric liver disease and extrahepatic portal vein obstruction or shunt. This study aimed to describe the changes that occur in children with chronic liver disease and extrahepatic portal vein obstruction or shunt. MATERIALS AND METHODS: We measured the concentration and activity of key procoagulant and anticoagulant factors in children with liver disease, children with extrahepatic portal vein obstruction or shunt, and healthy child..

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Grants

Funding Acknowledgements

This study was supported by research funding from the Murdoch Childrens Research Institute, the Victorian Government's Operational Infrastructure Support Program, Samaritan Foundation, the Sven Jerring Foundation, the Swedish Order of Freemasons, the HRH Crown princess Lovisa Foundation, Swedish Society of Medicine, and Karolinska Institutet foundation.