Sequencing of DICER1 in sarcomas identifies biallelic somatic DICER1 mutations in an adult-onset embryonal rhabdomyosarcoma
Leanne de Kock, Barbara Rivera, Timothee Revil, Paul Thorner, Catherine Goudie, Dorothee Bouron-Dal Soglio, Catherine S Choong, John R Priest, Paul J van Diest, Jantima Tanboon, Anja Wagner, Jiannis Ragoussis, Peter FM Choong, William D Foulkes
British Journal of Cancer | NATURE PUBLISHING GROUP | Published : 2017
We thank the patients for their participation in the study, Ms Leanne Taylor, Ms Brooke Backman, and Mr HJ Dubbink for providing pathology material, and Dr Leon van Kempen, Dr George Chong, and Karin Delorme of the Molecular Diagnostics Laboratory, Jewish General Hospital, for assistance with the TruSight Tumor 15 capture and sequencing of case 1. We also thank Nelly Sabbaghian for assistance with the MLPA assay, and Dr Tara Paton and Guillermo Casallo of The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Canada, for assistance with the ddPCR experiments. A portion of biospecimens and data used in this research were obtained from the Victorian Cancer Biobank, Victoria, Australia, with appropriate ethics approval. The Victorian Cancer Biobank is supported by the Victorian Government. This work was supported by Alex's Lemonade Stand Foundation and by C<SUP>17</SUP>, the latter with funding from Childhood Cancer Canada Foundation (to WDF), the Vanier Canada Graduate Scholarship (to LdK), and the Kate McGarrigle Fellowship in Sarcoma Research of the Cedars Cancer Centre (to BR).