Journal article

Regional Volume Characteristics of the Preterm Infant Receiving First Intention Continuous Positive Airway Pressure

Risha Bhatia, Peter G Davis, David G Tingay



OBJECTIVE: To determine whether applying nasal continuous positive airway pressure (CPAP) using systematic changes in continuous distending pressure (CDP) results in a quasi-static pressure-volume relationship in very preterm infants receiving first intention CPAP in the first 12-18 hours of life. STUDY DESIGN: Twenty infants at <32 weeks' gestation with mild respiratory distress syndrome (RDS) managed exclusively with nasal CPAP had CDP increased from 5 to 8 to 10 cmH2O, and then decreased to 8 cmH2O and returned to baseline CDP. Each CDP was maintained for 20 min. At each CDP, relative impedance change in end-expiratory thoracic volume (ΔZEEV) and tidal volume (ΔZVT) were measured using el..

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Awarded by European Union

Funding Acknowledgements

We thank Susan Donath for statistical advice, Brenda Argus for assistance with the study, Dr Emanuela Zannin and Elroy Zonneveld for assistance with data management, and Dr Inez Frerichs for assistance with data analysis (supported by The European Union's 7th Framework Programme for Research and Technological Development [WELCOME Project, 611223] and the European Union's Framework Programme for Research and Innovation Horizon 2020 [CRADL Project, 668259], and reimbursement of speaking and congress fees as well as travel costs from Drager).