Journal article

Local introduction and heterogeneous spatial spread of dengue-suppressing Wolbachia through an urban population of Aedes aegypti

Tom L Schmidt, Nicholas H Barton, Gordana Rasic, Andrew P Turley, Brian L Montgomery, Inaki Iturbe-Ormaetxe, Peter E Cook, Peter A Ryan, Scott A Ritchie, Ary A Hoffmann, Scott L O'Neill, Michael Turelli

PLoS Biology | PUBLIC LIBRARY SCIENCE | Published : 2017

Abstract

Dengue-suppressing Wolbachia strains are promising tools for arbovirus control, particularly as they have the potential to self-spread following local introductions. To test this, we followed the frequency of the transinfected Wolbachia strain wMel through Ae. aegypti in Cairns, Australia, following releases at 3 nonisolated locations within the city in early 2013. Spatial spread was analysed graphically using interpolation and by fitting a statistical model describing the position and width of the wave. For the larger 2 of the 3 releases (covering 0.97 km2 and 0.52 km2), we observed slow but steady spatial spread, at about 100-200 m per year, roughly consistent with theoretical predictions...

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Grants

Awarded by National Health and Medical Research Council


Awarded by NIH


Awarded by NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES


Funding Acknowledgements

FNIH as part of the Grand Challenges program of the Bill and Melinda Gates Foundation. FNIH funding to SLO. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.National Health and Medical Research Council (grant number 1044698). NHMRC to SAR. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. National Health and Medical Research Council. NHMRC program and fellowship funding to AAH. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NIH (grant number R01 GM104325). NIH funding to MT and AAH. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.