Journal article
Familial Analysis of Epistatic and Sex-Dependent Association of Genes of the Renin-Angiotensin-Aldosterone System and Blood Pressure
Katrina J Scurrah, Angela Lamantia, Justine A Ellis, Stephen B Harrap
CIRCULATION-CARDIOVASCULAR GENETICS | LIPPINCOTT WILLIAMS & WILKINS | Published : 2017
Abstract
BACKGROUND: Renin-angiotensin-aldosterone system genes have been inconsistently associated with blood pressure, possibly because of unrecognized influences of sex-dependent genetic effects or gene-gene interactions (epistasis). METHODS AND RESULTS: We tested association of systolic blood pressure with single-nucleotide polymorphisms (SNPs) at renin (REN), angiotensinogen (AGT), angiotensin-converting enzyme (ACE), angiotensin II type 1 receptor (AGTR1), and aldosterone synthase (CYP11B2), including sex-SNP or SNP-SNP interactions. Eighty-eight tagSNPs were tested in 2872 white individuals in 809 pedigrees from the Victorian Family Heart Study using variance components models. Three SNPs (rs8..
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Funding Acknowledgements
This work was supported by the Victorian Health Promotion Foundation, the National Health and Medical Research Council of Australia, and the Heart Foundation of Australia. This research was facilitated through the Twins Research Australia receives support from the National Health and Medical Research Council through a Centre of Research Excellence Grant, from which Dr Scurrah is also partially funded. Dr Ellis was supported by an Australian Research Council Future Fellowship.