Journal article

Winding back Wnt signalling: potential therapeutic targets for treating gastric cancers

Dustin J Flanagan, Elizabeth Vincan, Toby J Phesse

BRITISH JOURNAL OF PHARMACOLOGY | WILEY | Published : 2017

Abstract

Gastric cancer persists as a frequent and deadly disease that claims over 700 000 lives annually. Gastric cancer is a multifactorial disease that is genetically, cytologically and architecturally more heterogeneous than other gastrointestinal cancers, making it therapeutically challenging. As such, and largely attributed to late-stage diagnosis, gastric cancer patients show only partial response to standard chemo and targeted molecular therapies, highlighting an urgent need to develop new targeted therapies for this disease. Wnt signalling has a well-documented history in the genesis of many cancers and is, therefore, an attractive therapeutic target. As such, drug discovery has focused on d..

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Grants

Awarded by National Health and Medical Research Council of Australia (NHMRC) project


Awarded by Melbourne Health project


Awarded by Cancer Council of Victoria project grants (CCV)



Funding Acknowledgements

The authors wish to thank Gavan Mitchell for helping generate the figures in this manuscript. Funding is gratefully acknowledged from the following; National Health and Medical Research Council of Australia (NHMRC) project grants (566679 and APP1099302 awarded to E.V.); Melbourne Health project grants (605030 and PG-002 awarded to E.V./T.J.P.), and an Early Career Researcher grant (GIA-033) awarded to D.J.F.; Cancer Council of Victoria project grants (CCV, APP1020716) awarded to E.V. and T.J.P., CCV Fellowship awarded to D.J.F. and Cardiff University Research Fellowship awarded to T.J.P.