Journal article

Wnt is necessary for mesenchymal to epithelial transition in colorectal cancer cells

Renate HM Schwab, Nancy Amin, Dustin J Flanagan, Timothy M Johanson, Toby J Phesse, Elizabeth Vincan



BACKGROUND: Metastasis underlies most colorectal cancer mortality. Cancer cells spread through the body as single cells or small clusters of cells that have an invasive, mesenchymal, nonproliferative phenotype. At the secondary site, they revert to a proliferative "tumor constructing" epithelial phenotype to rebuild a tumor. We previously developed a unique in vitro three-dimensional model, called LIM1863-Mph, which faithfully recapitulates these reversible transitions that underpin colorectal cancer metastasis. Wnt signaling plays a key role in these transitions and is initiated by the coupling of extracellular Wnt to Frizzled (FZD). Using the LIM1863-Mph model system we demonstrated that t..

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Awarded by Australian National Health & Medical Research Council (NHMRC)

Awarded by Melbourne Health

Awarded by Cancer Council of Victoria (CCV)

Funding Acknowledgements

Grant sponsor: the Australian National Health & Medical Research Council (NHMRC); Grant number: 566679; Grant number: APP1099302; Grant sponsor: Melbourne Health; Grant number: 605030; Grant number: 605030; Grant number: Early career researcher grant GIA-033; Grant sponsor: Cancer Council of Victoria; Grant number: CCV, APP1020716; Grant sponsor: Cardiff University/Capital Medical University.