Journal article

In Vivo Laser Confocal Microscopy Using the HRT-Rostock Cornea Module: Diversity and Diagnostic Implications in Patients with Uveitis

Lyndell L Lim, Jing Xie, Chyn C Chua, Tiffany Wong, Lani T Hoang, Matthias D Becker, Eric B Suhler, James T Rosenbaum, Friederike Mackensen

OCULAR IMMUNOLOGY AND INFLAMMATION | TAYLOR & FRANCIS INC | Published : 2018

Abstract

PURPOSE: Keratic precipitates (KP) are a common feature of uveitis. We prospectively examined KP with the Heidelberg Retinal Tomograph II confocal laser scanning microscope and Rostock Corneal Module (HRT-RCM) to explore their diagnostic implications. METHODS: Prospective, observational, multicenter study. HRT-RCM images were classified by two masked observers. RESULTS: 120 scans on 120 eyes from 110 subjects were included. The majority (N = 93) had non-infectious uveitis. Sixty eyes had active disease at scanning. Eight KP morphologies were defined. Agreement between the two masked graders was high (Kappa value across all categories = 0.81). Cluster and nodular KP were associated with activ..

View full abstract

Grants

Awarded by NHMRC


Funding Acknowledgements

CERA receives Operational Infrastructure Support from the Victorian Government. Authors JTR and EBS are supported by an unrestricted grant from Research to Prevent Blindness; EBS is also supported by the Department of Veterans Affairs. LLL is also supported by an NHMRC Early Career Fellowship (APP 1109330).