Journal article
In Vivo Laser Confocal Microscopy Using the HRT-Rostock Cornea Module: Diversity and Diagnostic Implications in Patients with Uveitis
Lyndell L Lim, Jing Xie, Chyn C Chua, Tiffany Wong, Lani T Hoang, Matthias D Becker, Eric B Suhler, James T Rosenbaum, Friederike Mackensen
OCULAR IMMUNOLOGY AND INFLAMMATION | TAYLOR & FRANCIS INC | Published : 2018
Abstract
PURPOSE: Keratic precipitates (KP) are a common feature of uveitis. We prospectively examined KP with the Heidelberg Retinal Tomograph II confocal laser scanning microscope and Rostock Corneal Module (HRT-RCM) to explore their diagnostic implications. METHODS: Prospective, observational, multicenter study. HRT-RCM images were classified by two masked observers. RESULTS: 120 scans on 120 eyes from 110 subjects were included. The majority (N = 93) had non-infectious uveitis. Sixty eyes had active disease at scanning. Eight KP morphologies were defined. Agreement between the two masked graders was high (Kappa value across all categories = 0.81). Cluster and nodular KP were associated with activ..
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Awarded by NHMRC
Funding Acknowledgements
CERA receives Operational Infrastructure Support from the Victorian Government. Authors JTR and EBS are supported by an unrestricted grant from Research to Prevent Blindness; EBS is also supported by the Department of Veterans Affairs. LLL is also supported by an NHMRC Early Career Fellowship (APP 1109330).