Optineurin suppression activates the mediators involved in the terminal effector pathways of human labour and delivery

R Lim; G Barker; M Lappas

Journal article

Optineurin suppression activates the mediators involved in the terminal effector pathways of human labour and delivery

R Lim, G Barker, M Lappas

Reproduction Fertility and Development | CSIRO PUBLISHING | Published : 2017

DOI: 10.1071/RD15494

Abstract

Spontaneous preterm birth remains the major cause of neonatal death and morbidity. Studies in non-gestational tissues report that optineurin (OPTN) is critical in the termination of NFKB1 activity and control of inflammation, central features of spontaneous preterm birth. The aims of the present study were to determine: (1) OPTN expression in fetal membranes and the myometrium during labour; (2) the effects of IL1B on OPTN expression in primary myometrial cells; and (3) the effects of OPTN short interference (si) RNA on IL1B-stimulated proinflammatory and prolabour mediators. OPTN mRNA and protein expression was significantly decreased with spontaneous term labour in fetal membranes and the ..

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University of Melbourne Researchers

Martha Lappas Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

The authors gratefully acknowledge clinical Research Midwives Genevieve Christophers, Gabrielle Pell and Rachel Murdoch for sample collection and the Obstetrics and Midwifery staff of the Mercy Hospital for Women for their cooperation. ML is supported by a Career Development Fellowship from the National Health and Medical Research Council (NHMRC; Grant no. 1047025). Funding for this study was provided by the NMHRC (Grant no. 1058786), Medical Research Foundation for Women and Babies and the Mercy Research Foundation.