Journal article
Tenecteplase in ischemic stroke offers improved recanalization
A Bivard, X Huang, CR Levi, N Spratt, BCV Campbell, BK Cheripelli, D Kalladka, FC Moreton, I Ford, CF Bladin, SM Davis, GA Donnan, KW Muir, MW Parsons
Neurology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2017
Abstract
Objective: To test whether patients with complete vessel occlusion show greater recanalization at 24 hours and have improved clinical outcomes at 24 hours and 90 days when treated with tenecteplase compared to alteplase. Methods: Pooled clinical and imaging data from 2 phase 2 randomized trials comparing tenecteplase with alteplase allowed CT angiography (CTA) scans to be assessed centrally for occlusion status at baseline and at 24 hours post thrombolysis using the modified thrombolysis in cerebral infarction (TICI) scale. Twenty-four-hour poststroke NIH Stroke Scale (NIHSS) and 90-day modified Rankin Scale (mRS) scores were also compared between treatment groups using linear regression to ..
View full abstractGrants
Awarded by Medical Research Council
Funding Acknowledgements
The Australian-TNK study was funded by the National Health and Medical Research Council. The ATTEST study was funded by the UK Stroke Association.