Translating Cough Mechanisms Into Better Cough Suppressants
Jennifer A Keller, Alice E McGovern, Stuart B Mazzone
CHEST | ELSEVIER SCIENCE BV | Published : 2017
Chronic cough is a significant problem, and in many patients cough remains refractive to both disease-specific therapies and current cough-suppressing medicines, creating a need for improved antitussive therapies. Most patients with chronic cough also display heightened sensitivity so that they experience a persistent sense of the need to cough, and often innocuous stimuli can trigger their coughing. This hypersensitivity underpins the newly described concept of cough hypersensitivity syndrome (CHS), a term that encapsulates the notion of common underlying mechanisms producing neuronal activation, sensitization and/or dysfunction, which are at the core of excessive coughing. Understanding th..View full abstract
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Awarded by National Health and Medical Research Council of Australia
Awarded by NHMRC of Australia
The authors have reported to CHEST the following: S. B. M. is supported by a grant from the National Health and Medical Research Council of Australia No. 1078943. A. E. M. is a current NHMRC of Australia Research Fellow No. 1121376. None declared (J. A. K.).