Journal article
Erythropoietin in patients with traumatic brain injury and extracranial injury - A post hoc analysis of the erythropoietin traumatic brain injury trial
MB Skrifvars, M Bailey, C French, J Presneill, A Nichol, L Little, J Duranteau, O Huet, S Haddad, Y Arabi, C McArthur, DJ Cooper, R Bellomo
Journal of Trauma and Acute Care Surgery | LIPPINCOTT WILLIAMS & WILKINS | Published : 2017
Abstract
BACKGROUND Erythropoietin (EPO) may reduce mortality after traumatic brain injury (TBI). Secondary brain injury is exacerbated by multiple trauma, and possibly modifiable by EPO. We hypothesized that EPO decreases mortality more in TBI patients with multiple trauma, than in patients with TBI alone. METHODS A post hoc analysis of the EPO-TBI randomized controlled trial conducted in 2009 to 2014. To evaluate the impact of injuries outside the brain, we calculated an extracranial Injury Severity Score (ISS) that included the same components of the ISS, excluding head and face components. We defined multiple trauma as two injured body regions with an Abbreviated Injury Scale (AIS) score of 3 or ..
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Awarded by National Health and Medical Research Council of Australia
Awarded by Transport Accident Commission of Victoria
Funding Acknowledgements
EPO-TBI was supported by grants from the National Health and Medical Research Council of Australia (grant 545902) and the Transport Accident Commission of Victoria (grant D162). M.S. has received personal research funding from Medicinska Understodsforeningen Liv och Halsa, Finska Lakaresallskapet and Svenska Kulturfonden. A.N. has received support from the Health Research Board of Ireland.