Journal article
Early, goal-directed therapy for septic shock - A patient-level meta-analysis
KM Rowan, DC Angus, M Bailey, AE Barnato, R Bellomo, RR Canter, TJ Coats, A Delaney, E Gimbel, RD Grieve, DA Harrison, AM Higgins, B Howe, DT Huang, JA Kellum, PR Mouncey, E Music, SL Peake, F Pike, MC Reade Show all
New England Journal of Medicine | MASSACHUSETTS MEDICAL SOC | Published : 2017
Abstract
BACKGROUND: After a single-center trial and observational studies suggesting that early, goaldirected therapy (EGDT) reduced mortality from septic shock, three multicenter trials (ProCESS, ARISE, and ProMISe) showed no benefit. This meta-analysis of individual patient data from the three recent trials was designed prospectively to improve statistical power and explore heterogeneity of treatment effect of EGDT. METHODS: We harmonized entry criteria, intervention protocols, outcomes, resource-use measures, and data collection across the trials and specified all analyses before unblinding. After completion of the trials, we pooled data, excluding the protocolbased standard-therapy group from th..
View full abstractGrants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
Funded by the National Institute of General Medical Sciences and others; PRISM ClinicalTrials.gov number, NCT02030158.