Journal article

An atypical role for the myeloid receptor Mincle in central nervous system injury

Thiruma V Arumugam, Silvia Manzanero, Milena Furtado, Patrick J Biggins, Yu-Hsuan Hsieh, Mathias Gelderblom, Kelli PA MacDonald, Ekaterina Salimova, Yu-I Li, Othmar Korn, Deborah Dewar, I Mhairi Macrae, Robert B Ashman, Sung-Chun Tang, Nadia A Rosenthal, Marc J Ruitenberg, Tim Magnus, Christine A Wells

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | SAGE PUBLICATIONS INC | Published : 2017

Abstract

The C-type lectin Mincle is implicated in innate immune responses to sterile inflammation, but its contribution to associated pathologies is not well understood. Herein, we show that Mincle exacerbates neuronal loss following ischemic but not traumatic spinal cord injury. Loss of Mincle was beneficial in a model of transient middle cerebral artery occlusion but did not alter outcomes following heart or gut ischemia. High functional scores in Mincle KO animals using the focal cerebral ischemia model were accompanied by reduced lesion size, fewer infiltrating leukocytes and less neutrophil-derived cytokine production than isogenic controls. Bone marrow chimera experiments revealed that the pre..

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University of Melbourne Researchers

Grants

Awarded by Australian National Health & Medical Research Council


Awarded by Singapore National Medical Research Council Collaborative Research Grant


Funding Acknowledgements

The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was funded by Australian National Health & Medical Research Council (1057846, 1060538 and Fellowship to NAR), Spinal Cure Australia (Career Development Fellowship to MJR), the Australian Research Council, Singapore National Medical Research Council Collaborative Research Grant (NMRC-CBRG-0102/2016 to TA), the State Government of Victoria, the Australian Government and The University of Queensland.