Journal article

Associations of Newborn Brain Magnetic Resonance Imaging with Long-Term Neurodevelopmental Impairments in Very Preterm Children

PJ Anderson, K Treyvaud, JJ Neil, JLY Cheong, RW Hunt, DK Thompson, KJ Lee, LW Doyle, TE Inder

Journal of Pediatrics | Published : 2017

Abstract

Objective To determine the relationship between brain abnormalities on newborn magnetic resonance imaging (MRI) and neurodevelopmental impairment at 7 years of age in very preterm children. Study design A total of 223 very preterm infants (<30 weeks of gestation or <1250 g) born at Melbourne's Royal Women's Hospital had a brain MRI scan at term equivalent age. Scans were scored using a standardized system that assessed structural abnormality of cerebral white matter, cortical gray matter, deep gray matter, and cerebellum. Children were assessed at 7 years on measures of general intelligence, motor functioning, academic achievement, and behavior. Results One hundred eighty-six very preterm ch..

View full abstract

Grants

Awarded by Foundation for the National Institutes of Health


Funding Acknowledgements

Supported by Australia's National Health and Medical Research Council, including Centre for Clinical Research Excellence (546519), Center for Research Excellence (1060733), Project Grants (237117 and 491209), Senior Research Fellowship (1081288 [to P.A.]), Career Development Fellowship (1085754 [to D.T.]), Early Career Fellowship (1012236 [to D.K] and 1053787 [to J.C.]). Also supported by the Victorian Government's Operational Infrastructure Support Program and the US National Institutes of Health (HD058056). The authors have no conflicts of interest.