Journal article

Primary HPV testing versus cytology-based cervical screening in women in Australia vaccinated for HPV and unvaccinated: effectiveness and economic assessment for the National Cervical Screening Program

Jie-Bin Lew, Kate T Simms, Megan A Smith, Michaela Hall, Yoon-Jung Kang, Xiang Ming Xu, Michael Caruana, Louiza Sofia Velentzis, Tracey Bessell, Marion Saville, Ian Hammond, Karen Canfell

LANCET PUBLIC HEALTH | ELSEVIER SCI LTD | Published : 2017

Abstract

BACKGROUND: Australia's National Cervical Screening Program currently recommends cytological screening every 2 years for women aged 18-69 years. Human papillomavirus (HPV) vaccination was implemented in 2007 with high population coverage, and falls in high-grade lesions in young women have been reported extensively. This decline prompted a major review of the National Cervical Screening Program and new clinical management guidelines, for which we undertook this analysis. METHODS: We did effectiveness modelling and an economic assessment of potential new screening strategies, using a model of HPV transmission, vaccination, natural history, and cervical screening. First, we evaluated 132 scree..

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