Journal article
Survival and Complications Following Surgery and Radiation for Localized Prostate Cancer: An International Collaborative Review
CJD Wallis, A Glaser, JC Hu, H Huland, N Lawrentschuk, D Moon, DG Murphy, PL Nguyen, MJ Resnick, RK Nam
European Urology | ELSEVIER SCIENCE BV | Published : 2018
Abstract
Background Evaluation of treatment options for localized prostate cancer (PCa) remains among the highest priorities for comparative effectiveness research. Surgery and radiotherapy (RT) are the two interventions most commonly used. Objective To provide a critical narrative review of evidence of the comparative effectiveness and harms of surgery and RT in the treatment of localized PCa. Evidence acquisition A collaborative critical narrative review of the literature was conducted. Evidence synthesis Evidence to clearly guide treatment choice in PCa remains insufficient. Randomized trials are underpowered for clinically meaningful endpoints and have demonstrated no difference in overall or PCa..
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Funding Acknowledgements
Christopher J.D. Wallis certifies that all conflicts of interest, including specific financial interests and relationships and affiliations relevant to the subject matter or materials discussed in the manuscript (eg, employment/affiliation, grants or funding, consultancies, honoraria, stock ownership or options, expert testimony, royalties, or patents filed, received, or pending), are the following: Jim C. Hu has received speaker fees from Intuitive Surgical and Genomic Health. Declan G. Murphy has received advisory and speaker fees from Astellas, Janssen, Ipsen, Sanofi, and Ferring. Paul L. Nguyen has received consulting fees from Ferring, Medivation, Genome Dx, Dendreon, and Nanobiotix, and research funding from Astellas and Janssen. The remaining authors have nothing to disclose.