Journal article
Genome-wide association study identifies multiple risk loci for renal cell carcinoma
G Scelo, MP Purdue, KM Brown, M Johansson, Z Wang, JE Eckel-Passow, Y Ye, JN Hofmann, J Choi, M Foll, V Gaborieau, MJ Machiela, LM Colli, P Li, JN Sampson, B Abedi-Ardekani, C Besse, H Blanche, A Boland, L Burdette Show all
Nature Communications | NATURE PUBLISHING GROUP | Published : 2017
DOI: 10.1038/ncomms15724
Open access
Abstract
Previous genome-wide association studies (GWAS) have identified six risk loci for renal cell carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and 7,331 controls together with four existing scans, totalling 10,784 cases and 20,406 controls of European ancestry. Twenty-four loci were tested in an additional 3,182 cases and 6,301 controls. We confirm the six known RCC risk loci and identify seven new loci at 1p32.3 (rs4381241, P = 3.1×10-10), 3p22.1 (rs67311347, P = 2.5×10-8), 3q26.2 (rs10936602, P = 8.8×10-9), 8p21.3 (rs2241261, P = 5.8×10-9), 10q24.33-q25.1 (rs11813268, P = 3.9×10-8), 11q22.3 (rs74911261, P = 2.1×10-10) and 14q24.2 (rs4903064, P = 2.2×10-24). Expr..
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Awarded by National Institutes of Health
Funding Acknowledgements
The authors thank all of the participants who took part in this research and the funders and support staff who made this study possible. Funding for the genome-wide genotyping was provided by the US National Institutes of Health (NIH), National Cancer Institute (U01CA155309) for those studies coordinated by IARC and by the intramural research program of the National Cancer Institute, US NIH, for those studies coordinated by the NCI. Funding for the IARC gene expression and eQTL study was provided by the US National Institutes of Health (NIH), National Cancer Institute (U01CA155309). Additional acknowledgements can be found in Supplementary Note.