Journal article

Loss of the Wnt receptor frizzled 7 in the mouse gastric epithelium is deleterious and triggers rapid repopulation in vivo

Dustin J Flanagan, Nick Barker, Cameron Nowell, Hans Clevers, Matthias Ernst, Toby J Phesse, Elizabeth Vincan



The gastric epithelium consists of tubular glandular units, each containing several differentiated cell types, and populations of stem cells, which enable the stomach to secrete the acid, mucus and various digestive enzymes required for its function. Very little is known about which cell signalling pathways are required for homeostasis of the gastric epithelium. Many diseases, such as cancer, arise as a result of deregulation of signalling pathways that regulate homeostasis of the diseased organ. Therefore, it is important to understand the biology of how normal conditions are maintained in a tissue to help inform the mechanisms driving disease in that same tissue, and to identify potential ..

View full abstract


Awarded by National Health and Medical Research Council of Australia

Awarded by Melbourne Health project grants

Awarded by Cancer Council Victoria project grants

Awarded by National Breast Cancer Foundation

Funding Acknowledgements

Funding is gratefully acknowledged from the following: National Health and Medical Research Council of Australia (566679 and APP1099302); Melbourne Health project grants (605030 and PG-002) and early career researcher grant (GIA-033) awarded to D.J.F.; Cancer Council Victoria project grants (APP1020716) awarded to E.V. and T.J.P.; Cancer Council Victoria Fellowship awarded to D.J.F.; and a Cardiff University Research Fellowship awarded to T.J.P.