Journal article
Whipworm kinomes reflect a unique biology and adaptation to the host animal
Andreas J Stroehlein, Neil D Young, Pasi K Korhonen, Bill CH Chang, Peter Nejsum, Edoardo Pozio, Giuseppe La Rosa, Paul W Sternberg, Robin B Gasser
INTERNATIONAL JOURNAL FOR PARASITOLOGY | ELSEVIER SCI LTD | Published : 2017
Abstract
Roundworms belong to a diverse phylum (Nematoda) which is comprised of many parasitic species including whipworms (genus Trichuris). These worms have adapted to a biological niche within the host and exhibit unique morphological characteristics compared with other nematodes. Although these adaptations are known, the underlying molecular mechanisms remain elusive. The availability of genomes and transcriptomes of some whipworms now enables detailed studies of their molecular biology. Here, we defined and curated the full complement of an important class of enzymes, the protein kinases (kinomes) of two species of Trichuris, using an advanced and integrated bioinformatic pipeline. We investigat..
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Funding Acknowledgements
Research funding from the National Health and Medical Research Council of Australia (NHMRC), Australian Research Council (ARC), Australia and Wellcome Trust, UK, is gratefully acknowledged (R.B.G.). Support from the Australian Academy of Science - Australia, the Australian-American Fulbright Commission - Australia, Alexander von Humboldt Foundation (Germany), Melbourne Water Corporation (Australia) as well as the Victorian Life Sciences Computation Initiative (VLSCI), Australia, and WormBase (www.wormbase.org ) is gratefully acknowledged. We thank Brendan R.E. Ansell for providing the script to analyse the I-TASSER output. A.J.S. is a recipient of a Melbourne International Research Scholarship (MIRS) and a Melbourne International Fee Remission Scholarship (MIFRS) from the University of Melbourne, Australia. N.D.Y. holds an NHMRC Career Development Fellowship. P.K.K. is an NHMRC Early Career Research Fellow.