Journal article
The burden of cancer attributable to modifiable risk factors: The Australian cancer-PAF cohort consortium
ME Arriaga, CM Vajdic, K Canfell, R Macinnis, P Hull, DJ Magliano, E Banks, GG Giles, RG Cumming, JE Byles, AW Taylor, JE Shaw, K Price, V Hirani, P Mitchell, BA Adelstein, MA Laaksonen
BMJ Open | BMJ PUBLISHING GROUP | Published : 2017
Abstract
Purpose To estimate the Australian cancer burden attributable to lifestyle-related risk factors and their combinations using a novel population attributable fraction (PAF) method that accounts for competing risk of death, risk factor interdependence and statistical uncertainty. Participants 365 173 adults from seven Australian cohort studies. We linked pooled harmonised individual participant cohort data with population-based cancer and death registries to estimate exposure-cancer and exposure-death associations. Current Australian exposure prevalence was estimated from representative external sources. To illustrate the utility of the new PAF method, we calculated fractions of cancers causal..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This study was funded by the National Health and Medical Research Council (ID1060991; ID1053642 to MAL; ID1082989 to KC; ID1042717 to EB) and a Cancer Institute New South Wales Fellowship (ID13/ECF/1-07 to MAL). Maria Arriaga was supported by Australian Postgraduate Award and a Translational Cancer Research Network (TCRN) PhD Scholarship Top-up Award. The funding bodies played no role in the conduct of the study, the writing of the report or the decision to submit the paper for publication.