Journal article
Circulating levels of dickkopf-1, osteoprotegerin and sclerostin are higher in old compared with young men and women and positively associated with whole-body bone mineral density in older adults
J Coulson, L Bagley, Y Barnouin, S Bradburn, G Butler-Browne, H Gapeyeva, JY Hogrel, T Maden-Wilkinson, AB Maier, C Meskers, C Murgatroyd, M Narici, M Pääsuke, L Sassano, S Sipilä, N Al-Shanti, L Stenroth, DA Jones, JS McPhee
Osteoporosis International | SPRINGER LONDON LTD | Published : 2017
Abstract
Summary: Bone mineral density declines with increasing older age. We examined the levels of circulating factors known to regulate bone metabolism in healthy young and older adults. The circulating levels of dickkopf-1, osteocalcin, osteoprotegerin and sclerostin were positively associated with whole-body bone mineral density (WBMD) in older adults, despite the average WBMD being lower and circulating dickkopf-1, osteoprotegerin and sclerostin being higher in old than young. Introduction: This study aims to investigate the relationship between whole-body bone mineral density (WBMD) and levels of circulating factors with known roles in bone remodelling during ‘healthy’ ageing. Methods: WBMD an..
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Awarded by European Commission
Funding Acknowledgements
This project was supported by funding from European Union FP7 ('MYOAGE', #223576) and Medical Research Council (MR/K025252/1).