Journal article

Synergistic effect of IL-12 and IL-18 induces TIM3 regulation of gamma delta T cell function and decreases the risk of clinical malaria in children living in Papua New Guinea

Louis Schofield, Lisa J Ioannidis, Stephan Karl, Leanne J Robinson, Qiao Y Tan, Daniel P Poole, Inoni Betuela, Danika L Hill, Peter M Siba, Diana S Hansen, Ivo Mueller, Emily M Eriksson

BMC MEDICINE | BIOMED CENTRAL LTD | Published : 2017

Abstract

BACKGROUND: γδ T cells are important for both protective immunity and immunopathogenesis during malaria infection. However, the immunological processes determining beneficial or detrimental effects on disease outcome remain elusive. The aim of this study was to examine expression and regulatory effect of the inhibitory receptor T-cell immunoglobulin domain and mucin domain 3 (TIM3) on γδ T cells. While TIM3 expression and function on conventional αβ T cells have been clearly defined, the equivalent characterization on γδ T cells and associations with disease outcomes is limited. This study investigated the functional capacity of TIM3+ γδ T cells and the underlying mechanisms contributing to ..

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Grants

Awarded by NHMRC


Awarded by International Centers of Excellence in Malaria Research


Awarded by National Health and Medical Research Council (NHMRC)


Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


Funding Acknowledgements

This work was Supported by NHMRC grant APP106722 and the International Centers of Excellence in Malaria Research (grant U19 AI089686). This work was made possible through Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS. LJ.R was supported by a National Health and Medical Research Council (NHMRC) Early Career Fellowship #1016443. IM is supported by an NHMRC Senior Research Fellowship (#1043345). The funders had no role in study design, data collection and analysis; decision to publish, or preparation of the manuscript.