Antibiotic complications during the treatment of Mycobacterium ulcerans disease in Australian patients
Daniel P O'Brien, Deborah Friedman, Andrew Hughes, Aaron Walton, Eugene Athan
INTERNAL MEDICINE JOURNAL | WILEY | Published : 2017
BACKGROUND: Antibiotics are the recommended first-line treatment for Mycobacterium ulcerans disease. Antibiotic toxicity is common in Australian patients, yet antibiotic complication rates and their risk factors have not been determined. AIM: To determine the incidence rate and risk factors for antibiotic toxicity in Australian patients treated for M. ulcerans disease. METHODS: An analysis of severe antibiotic complications was performed using data from a prospective cohort of M. ulcerans cases managed at Barwon Health from 1 January 1998 to 30 June 2016. A severe antibiotic complication was defined as an antibiotic adverse event that required its cessation. Antibiotic complication rates and..View full abstract
Some funding for the study was received from the Education, Training and Research Profile Fund of Barwon Health.