Journal article

Antibiotic complications during the treatment of Mycobacterium ulcerans disease in Australian patients

Daniel P O'Brien, Deborah Friedman, Andrew Hughes, Aaron Walton, Eugene Athan

INTERNAL MEDICINE JOURNAL | WILEY | Published : 2017

Abstract

BACKGROUND: Antibiotics are the recommended first-line treatment for Mycobacterium ulcerans disease. Antibiotic toxicity is common in Australian patients, yet antibiotic complication rates and their risk factors have not been determined. AIM: To determine the incidence rate and risk factors for antibiotic toxicity in Australian patients treated for M. ulcerans disease. METHODS: An analysis of severe antibiotic complications was performed using data from a prospective cohort of M. ulcerans cases managed at Barwon Health from 1 January 1998 to 30 June 2016. A severe antibiotic complication was defined as an antibiotic adverse event that required its cessation. Antibiotic complication rates and..

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