Antibiotic complications during the treatment of Mycobacterium ulcerans disease in Australian patients

Abstract

Background: Antibiotics are the recommended first-line treatment for Mycobacterium ulcerans disease. Antibiotic toxicity is common in Australian patients, yet antibiotic complication rates and their risk factors have not been determined. Aim: To determine the incidence rate and risk factors for antibiotic toxicity in Australian patients treated for M. ulcerans disease. Methods: An analysis of severe antibiotic complications was performed using data from a prospective cohort of M. ulcerans cases managed at Barwon Health from 1 January 1998 to 30 June 2016. A severe antibiotic complication was defined as an antibiotic adverse event that required its cessation. Antibiotic complication rates and..