Journal article

A Brain Model of Disturbed Self-Appraisal in Depression

Christopher G Davey, Michael Breakspear, Jesus Pujol, Ben J Harrison

AMERICAN JOURNAL OF PSYCHIATRY | AMER PSYCHIATRIC PUBLISHING, INC | Published : 2017

Abstract

OBJECTIVE: A disturbed sense of self is a core feature of depression. The medial prefrontal cortex, which has a central role in self-appraisal processes, is often implicated in the illness, although it remains unclear how functional alterations of the region contribute to the observed disturbances. The aim of this study was to clarify the role of the medial prefrontal cortex in self-appraisal processes in depression. METHOD: The authors applied a recently developed dynamic network model of self-directed cognition to functional MRI data from 71 adolescents and young adults with moderate to severe major depressive disorder, none of whom were being treated with medication, and 88 healthy contro..

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Grants

Awarded by National Health and Medical Research Council of Australia (NHMRC)


Awarded by NHMRC


Funding Acknowledgements

Supported by National Health and Medical Research Council of Australia (NHMRC) Project Grants 1064643 (principal investigator, Dr. Harrison) and 1024570 (principal investigator, Dr. Davey).Dr. Davey and Dr. Harrison were supported by NHMRC Career Development Fellowships (1061757 and 1124472, respectively). The authors thank R. Kerestes and K. Stephanou for their contributions to data collection, as well as staff from the Sunshine Hospital Medical Imaging Department (Western Health, Melbourne).