Journal article
Time to lung aeration during a sustained inflation at birth is influenced by gestation in lambs
KE McCall, AD Waldmann, P Pereira-Fantini, R Oakley, M Miedema, EJ Perkins, PG Davis, PA Dargaville, SH Böhm, R Dellacà, M Sourial, E Zannin, AE Rajapaksa, A Tan, A Adler, I Frerichs, DG Tingay
Pediatric Research | NATURE PUBLISHING GROUP | Published : 2017
DOI: 10.1038/pr.2017.141
Abstract
Background: Current sustained lung inflation (SI) approaches use uniform pressures and durations. We hypothesized that gestational-age-related mechanical and developmental differences would affect the time required to achieve optimal lung aeration, and resultant lung volumes, during SI delivery at birth in lambs. Methods: 49 lambs, in five cohorts between 118 and 139 days of gestation (term 142 d), received a standardized 40 cmH 2 O SI, which was delivered until 10 s after lung volume stability (optimal aeration) was visualized on real-time electrical impedance tomography (EIT), or to a maximum duration of 180 s. Time to stable lung aeration (T stable) within the whole lung, gravity-dependen..
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Awarded by State Government of Victoria
Funding Acknowledgements
This study is supported by a National Health and Medical Research Council Project Grant, Canberra, Australia (Grant ID 1009287) and the Victorian Government Operational Infrastructure Support Program (Melbourne, Australia). D.G.T. is supported by a National Health and Medical Research Council Clinical Career Development Fellowship (Grant ID 1053889).