Journal article
Transforming growth factor β1–induced NADPH oxidase-4 expression and fibrotic response in conjunctival fibroblasts
KD Brown, MH Shah, GS Liu, EC Chan, JG Crowston, HM Peshavariya
Investigative Ophthalmology and Visual Science | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | Published : 2017
Abstract
PURPOSE. Fibrotic scarring after ocular surgeries and chemical burn injuries can impede clarity of the cornea and cause vision impairment. Transforming growth factor b (TGFb) signaling pathway is known to mediate fibrotic scarring, and NADPH oxidase–derived reactive oxygen species has been shown to be an effector molecule that facilitates TGFb1-mediated responses. The present study explores the expression profile and functional importance of NADPH oxidase (Nox) in conjunctival fibroblasts. In addition, the effect of curcumin on the TGFb1-induced NADPH oxidase expression and collagen synthesis was also investigated. METHODS. The mRNA expression of Nox isoforms in rabbit conjunctival fibroblas..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
Supported by National Health and Medical Research Council Research Project Grant APP1102092 and The Eye Research Australia Foundation. The Centre for Eye Research Australia received Operational Infrastructure Support from the Victorian Government.