Journal article

Impaired Downregulation of NKG2D Ligands by Nef Proteins from Elite Controllers Sensitizes HIV-1-Infected Cells to Antibody-Dependent Cellular Cytotoxicity

Nirmin Alsahafi, Jonathan Richard, Jeremie Prevost, Mathieu Coutu, Nathalie Brassard, Matthew S Parsons, Daniel E Kaufmann, Mark Brockman, Andres Finzi

Journal of Virology | AMER SOC MICROBIOLOGY | Published : 2017

University of Melbourne Researchers


Awarded by CIHR foundation grant

Awarded by amfAR innovation grant

Awarded by CIHR

Awarded by NIH


Funding Acknowledgements

We thank Florencia Pereyra, Bruce D. Walker, and all investigators who have contributed to The International HIV Controllers Study (, funded by the Mark and Lisa Schwarz Foundation, the Bill and Melinda Gates Foundation, and the AIDS Healthcare Foundation; the CRCHUM Flow Cytometry Platform for technical assistance as well as Mario Legault for cohort coordination; and all subjects for their participation and collaboration.This work was supported by a Canada Foundation for Innovation Program Leader grant, CIHR foundation grant 352417, and amfAR innovation grant 109343-59-RGRL, with support from FAIR to A.F. and by the FRQS AIDS and Infectious Diseases Network. A.F. and M.A.B. are supported by the Canada Research Chairs program. J.R. is the recipient of CIHR Fellowship Award 135349. N.A. is the recipient of a King Abdullah scholarship for higher education from the Saudi Government. M.S.P. is a recipient of a CIHR Fellowship Award. D.E.K. is supported by a Research Scholar Career Award of the Quebec Health Research Fund (FRQS). This study was also supported by NIH AI100645 and AI100663 Center for HIV/AIDS Vaccine Immunology and Immunogen Design (CHAVI-ID).